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Diagram illustrating that the phenotypes and function of circulating ILCs in OLP were altered, showing an imbalanced ILC1/ILC2 state with ILC1 activation and ILC2 suppression. Of note, elevated levels of IL-12 and IL-1β might act as environmental cues in tipping the balance of ILC1/ILC2 in peripheral blood of OLP, thus contributing to the immune dysregulation in OLP. ILCs, innate lymphoid cells; OLP, oral lichen planus.
