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. 2022 Feb 9;17:617–633. doi: 10.2147/IJN.S343902

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© 2022 Chen et al.

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Inhibition of iRGD-PSS@PBAE@JQ1/ORI NPs on the growth of breast cancer cells. The cytotoxicities of free JQ1, ORI, PSS@PBAE@JQ1/ORI and iRGD-PSS@PBAE@JQ1/ORI NPs in 4T1 cells after 24-hour treatments (A) and 48-hour treatments (B) at different JQ1 concentrations. (C) The LIVE/DEAD analysis of cells at 24 h after various treatments (Scale bar: 200 µm). (D) Cell apoptosis was quantified by flow cytometry at 24 h after various treatments (Q1: dead cells; Q2: late apoptotic cells; Q3: early apoptotic cells; Q4: live cells).