Table 1.

Pharmaceutical costs

	Administration	Strength/pack	Hospital prices—5%, unit cost (€)	Cost per mg (€)
Irinotecana	IV	20 mg/ml × 15 ml	147.31	0.47
Folinic acida	IV	10 mg/ml × 20 ml	11.2	0.03
Fluorouracila	IV	50 mg/ml × 100 ml	14.14	0.0028
Cetuximab	IV	5 mg/ml × 20 ml	132.26	1.32
Panitumumab	IV	20 mg/ml × 20 ml	1100.28	2.75
Bevacizumab	IV	25 mg/ml × 4ml	204.52	2.05
Aflibercept	Intravitreal	25 mg/ml × 4 ml	250.27	2.50
Oxaliplatin	IV	5 mg/ml × 10 ml	19.82	0.40
Capecitabine	Oral	150 mg/tab × 60 tabs	10.66	0.002
Nivolumab	IV	10 mg/ml × 24 ml	2106.87	8.78
Pembrolizumab	IV	25 mg/ml × 4 ml	2229.89	22.30
Encorafenib	Oral	75 mg/ml × 42 caps	1046.92	0.33
Tas102 (Trifluridine-tiporacil)	Oral	(15 + 6.14) mg/tab × 20 tabs	445.92	1.05
Regorafenib	Oral	40 mg/tab × 84 tabs	1884.71	0.56
Mitomycin-C	IV	2 mg/vial × 10 vials	15.91	0.84

For dosing schedules dependent on body weight or surface area, an average body weight of 70.7 kg and body surface area of 1.79 m² were used

^aIn the cases of Irinotecan, Folinic acid and Fluorouracil the cost per mg reflects the average price of generics/off patent which was used in the analysis