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. 2022 Jan 21;12(1):45–68. doi: 10.3233/JPD-212922

Table 1.

Pesticide exposure dose extrapolated from human to rodent (mouse and rat)

Risk Factor Primary Route of Exposure Exposure Limit/Maximum Contaminat Level Extrapolated Daily Dose in Mice Extrapolated Daily Dose in Rats
Paraquat Inhalation 0.1 mg/m3 † 1.22 mg/m3 0.6 mg/m3
Drinking Water 20 ppb 245μg/kg 123μg/kg

Time Weighted Average: 8-hour total weight average, particulate size dependent. Inhalation dose calculated using the fixed allometric exponent: Xh = Xa (Ma/Mh)1 - .67 without Uncertainty Factors [47], however dosage is dependent on particulate size and duration of exposure. Oral dose calculated using the U.S. FDA conversion guidelines, Human Equivalent Dose = animal dose in mg/kg x (animal weight in kg / human weight in kg)0.33 [46].