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. 2022 Jan 21;12(1):153–171. doi: 10.3233/JPD-212818

Table 3.

Top loci and variants associated with PD in MPBC from GWA analysis. Table showing the results from GWA analysis in MPBC along with information from summary statistics on the variants retrieved from the latest GWAS meta-analysis of individuals with European ancestry

Nearest gene(s) Top SNP CHR POS Effect allele Alt. allele EAF MAF Genotyped Rsq Beta OR SE p EAFa MAFa Betaa OR SEa p a
PLPP4 rs12771445 10 122318147 T C 0.314 0.314 Imputed 0.986 –0.411 0.663 0.072 1.30E-08 0.324 0.324 0.015 1.015 0.021 4.88E-01
SNCA rs356182 4 90626111 A G 0.617 0.383 Genotyped 0.997 –0.377 0.686 0.069 5.64E-08 0.616 0.384 –0.255 0.775 0.021 9.41E-34
COL12A1/ rs7752646 6 75447088 T G 0.873 0.127 Imputed 0.958 –0.715 0.489 0.106 4.13E-07 0.862 0.139 –0.060 0.942 0.033 6.62E-02
LOC105377858

aNalls 2019 without 23andMe data [12]. SNCA rs356182 can also be found in Supplementary Table 4. EAF, effect allele frequency; MAF, minor allele frequency; OR, odds ratio; CHR, chromosome; POS, position; SE, standard error.