Table 1.
Study Sample Characteristics
| Cases | All Controls (n = 251) | Control Sub-Categories | ||||
| PD in 3 years (n = 25) | PD in 5 years Case (n = 41) | LB-Unknown (n = 135) | LB-No (n = 32) | LB-Yes (n = 84) | ||
| Age at index date, mean (SD) | 81.4 (4.5) | 80.4 (4.3) | 81.1 (4.4) | 80.7 (4.1) | 81.4 (5.0) | 81.6 (4.7) |
| Years from index date until autopsy, mean (SD)* | 3.9 (1.21) | 5.5 (2.2) | 10.2 (3.9) | – | 10.8 (4.3) | 10.1 (3.8) |
| Simple reaction time, mean ms (SD) | 532.3 (245.9) | 483.9 (209) | 440.1 (163.3) | 446.3 (164.8) | 401.4 (87.4) | 445.5 (183.7) |
| Choice reaction time, mean ms (SD) | 701.7 (316.5) | 628.2 (263) | 573.7 (164.1) | 570.6 (153.7) | 538.9 (126.8) | 593.9 (192.6) |
| BMI kg/m2, mean (SD) | 24.2 (2.9) | 24.5 (3.0) | 23.9 (3.3) | 23.9 (3.3) | 23.0 (3.3) | 23. 8 (3.1) |
| Coffee oz/day, mean (SD) | 9.4 (6.4) | 9.7 (9.7) | 14 (13.1) | 14.6 (13.7) | 14.3 (12.1) | 12.8 (12.5) |
| CASI total score, mean (SD) ** | 81.4 (12.5) | 85.6 (11.3) | 84.4 (12.8) | 86.1 (8.8) | 86.8 (8.4) | 80.8 (18.1) |
| Olfaction BSIT score, median [range]*, ** | 4 [0–11] | 6 [0–11] | 7 [0–12] | 8 [0–12] | 7.5 [0–12] | 5 [0–12] |
| Bowel Movement Frequency* | ||||||
| < 1 every other day | 1 (4%) | 1 (2.4%) | 3 (1.2%) | 0 (0%) | 0 (0%) | 3 (3.6%) |
| Every other day | 5 (20%) | 9 (22%) | 13 (5.2%) | 6 (4.4%) | 0 (0%) | 7 (8.3%) |
| Once per day | 14 (56%) | 24 (58.5%) | 157 (62.6%) | 87 (64.4%) | 20 (62.5%) | 50 (59.5%) |
| 2–3 per day | 5 (20%) | 6 (14.7%) | 61 (24.3%) | 32 (23.8%) | 10 (31.3%) | 19 (22.6%) |
| > 3 per day | 0 (0%) | 0 (0%) | 8 (3.1%) | 3 (2.2%) | 1 (3.1%) | 4 (4.8%) |
| Missing | 0 (0%) | 1 (2.4%) | 9 (3.6%) | 7 (5.2%) | 1 (3.1%) | 1 (1.2%) |
| Excess Daytime sleepiness* | ||||||
| No | 19 (76%) | 34 (82.9%) | 230 (91.6.%) | 128 (94.8.%) | 31 (88.6%) | 71 (84.5%) |
| Yes | 6 (24%) | 7 (17.1%) | 18 (7.2%) | 7 (5.2%) | 1 (2.8%) | 10 (11.9%) |
| Missing | 0 (0.0%) | 0 (0%) | 3 (1.2%) | 0 (0%) | 3 (8.6%) | 3 (3.6%) |
| Traumatic Brain Injury | ||||||
| No | 22 (88%) | 34 (82.9%) | 211 (84.1%) | 118 (87.4%) | 26 (81.3%) | 67 (79.8%) |
| Yes | 3 (12%) | 7 (17.1%) | 28 (11.1%) | 11 (8.1%) | 6 (18.7%) | 11 (13.1%) |
| Missing | 0 (0%) | 0 (0%) | 12 (4.8%) | 6 (4.5%) | 0 (0.0%) | 6 (7.1%) |
| Smoking | ||||||
| Never | 9 (36%) | 14 (34.1%) | 99 (39.4%) | 53 (39.3%) | 11 (34.4%) | 35 (41.7%) |
| Past | 16 (64%) | 26 (63.4%) | 138 (55%) | 78 (57.8%) | 17 (53.1%) | 43 (51.2%) |
| Current | 0 (0.0%) | 1 (2.5%) | 14 (5.6%) | 4 (2.9%) | 4 (12.5%) | 6 (7.1%) |
| Hypertension | ||||||
| No | 7 (28%) | 11 (26.8%) | 71 (28.2%) | 33 (24.4%) | 8 (25%) | 30 (35.7%) |
| Yes | 18 (72%) | 30 (73.2%) | 180 (71.8%) | 102 (75.6%) | 24 (75%) | 54 (64.3%) |
*Significantly different (p < 0.05) between all cases and all controls. **Significantly different (p < 0.05) between LB-Yes and LB-No controls.