Table 1.

Median change of tremor and motor scores before and after FUS

	Baseline (N = 26)	1 month (N = 26)	6 months (N = 22)	12 months (N = 23)	24 months (N = 15)	36 months (N = 15)	48 months (N = 12)	60 months (N = 7)
UPDRS	22.5 (9–43)	–10 (–34 to 6)	–16 (–34 to 16)	–18 (–31 to 47)	–15 (–33 to –1)	–16 (–29 to 0)	–10 (–30 to –4)	–19 (–31 to –5)
		p < 0.0001	p < 0.0001	p < 0.0001	p < 0.0001	p = 0.0002	p = 0.0005	p = 0.016
Hemi–UPDRS	15 (5–24)	–9 (–19 to 4)	–12 (–18 to 2)	–12 (–20 to 6)	–12 (–17 to 2)	–10 (–17 to 2)	–8 (–16 to –3)	–8 (–17 to –4)
		p < 0.0001	p < 0.0001	p < 0.0001	p < 0.0001	p < 0.0001	p = 0.0005	p = 0.016
CRST	20 (9–70)	–15 (–66 to –5)	–17.5 (–64 to –5)	–17 (–63 to –5)	–20 (–69 to –6)	–14 (–70 to 6)	–15 (–54 to 6)	–14 (–54 to 3)
		p < 0.0001	p < 0.0001	p < 0.0001	p < 0.0001	p = 0.015	p = 0.013	p = 0.031
Hemi-CRST	13 (5–28)	–12 (–28 to –4)	–13 (–28 to 2)	–13 (–28 to 2)	–14 (–28 to 1)	–13 (–28 to 1)	–14.5 (–28 to 0)	–8 (–28 to 1)
		p < 0.0001	p < 0.0001	p < 0.0001	p < 0.0001	p = 0.0002	p = 0.0010	p = 0.031
PDQ39	32 (17–79)	–18* (–42 to 27)	–19 (–61 to 9)	–15 (–66 to 11)	–7 (–43 to 15)	–8 (–46 to 24)	–6 (–48 to 29)	–11 (–47 to 24)
		p < 0.0001	p < 0.0001	p < 0.0001	NS	NS	NS	NS
Levodopa equivalent	300 (0–1050)	0 (–200 to 141)	0 (–200 to 582)	0 (–200 to 985)	66 (–250 to 1676)	199 (–250 to 1076)	122.5 (–250 to 1676)	151 (0 to 1476)
		NS	NS	NS	NS	p = 0.0049	p = 0.037	p = 0.031

Baseline scores are reported as raw values. For all other outcome parameters median change from baseline (follow-up –baseline) and range of change are reported. UPDRS is the Unified Parkinson’s Disease Rating Scale part III, Hemi-UPDRS is-the treated hemibody UPDRS, CRST is Clinical Rating Scale for Tremor, and Hemi-CRST is the treated hemibody CRST. Negative values indicate improvement on all scales. p values are based on Wilcoxon signed rank test of changes (follow-up –baseline). ^*N = 25 for this item.