Fig. 4.

Association between [¹⁸F]GTP1 SUVR and CSF p-tau measures. Correlation comparison (Spearman r) between measures of amyloid PET centiloid and brain tau aggregation in various regions of interest using [¹⁸F]GTP1 SUVR in select regions of interest (temporal meta: tmp_metaROI, whole cortical grey:WCG, Braak12, Braak34, Braak56) with CSF p-tau measures (middle sites: “pT217 cluster”) and amyloid PET in (A) Cohort A, and (B) Cohort B. Correlation between [¹⁸F]GTP1 SUVR (tmp_metaROI) and CSF tau phosphorylation occupancy on T217 in (C) Cohort A and (D) Cohort B. Correlation between Aβ PET(centiloid) and CSF tau phosphorylation occupancy on T217 in (E) Cohort A and (F) Cohort B. Empty triangle, CN- (cognitively normal); solid triangle, CN+; orange, prodromal AD; blue, mild AD; gray, moderate AD. Elecsys pTau181 level (pg/mL):E_pT181l, Elecsys pTau181/tTau ratio: E_pT181, MS pTau/uTau ratios: pX###