Table 1.
Patient demographic and disease characteristics expressed as mean (SD).
| Cohort A | Cohort B | ||||||
| CN– | CN+ | Prodromal | Mild | Moderate | Prodromal | Mild | |
| (n = 6) | (n = 5) | (n = 13) | (n = 12) | (n = 10) | (n = 24) | (n = 40) | |
| Age | 59 (8.22) | 68.63 (3.38) | 69.81 (6.85) | 70.6 (6.14) | 70.87 (7.02) | 70.71 (7.06) | 69.28 (7.47) |
| Female | 3 (50%) | 2 (40%) | 7 (54%) | 8 (67%) | 2 (20%) | 10 (42%) | 17 (43%) |
| Caucasian descent | 6 (100%) | 4 (80%) | 13 100%) | 11 (92%) | 9 (90%) | 23 (96%) | 33 (83%) |
| MMSE | 29.33 (0.82) | 29.00 (0.71) | 28.31 (1.18) | 26.58 (2.47) | 17.60 (2.76) | 25.83 (2.70) | 23.03 (2.48) |
| CDRSB | 0.00 (0.00) | 0.10 (0.22) | 1.58 (0.91) | 3.18 (1.27) | 6.22 (1.72) | 2.56 (1.15) | 4.72 (1.85) |
| ADAS13 | 12.34 (4.72) | 8.00 (4.75) | 15.31 (6.11) | 19.24 (6.87) | 39.78 (7.29) | 22.53 (7.39) | 29.57 (6.84) |
| RBANS-Total | 98.50 (3.54) | 91.8 (11.56) | 85.23 (9.28) | 77 (14.55) | 60.5 (12.12) | 76.13 (13.50) | 61.24 (11.83) |
| [18F]GTP1-PET Temp ROI SUVR | 1.02 (0.05) | 1.26 (0.05) | 1.36 (0.19) | 1.5 (0.26) | 1.67 (0.32) | 1.42 (0.34) | 1.52 (0.37) |
| [18F]GTP1-PET WCG SUVR | 1.00 (0.05) | 1.17 (0.05) | 1.18 (0.10) | 1.34 (0.27) | 1.45 (0.41) | 1.2 (0.21) | 1.31 (0.26) |
| [18F]GTP1-PET Braak12 SUVR | 1.00 (0.05) | 1.27 (0.04) | 1.36 (0.17) | 1.44 (0.14) | 1.48 (0.26) | 1.39 (0.22) | 1.41 (0.22) |
| [18F]GTP1-PET Braak34 SUVR | 1.00 (0.05) | 1.2 (0.05) | 1.27 (0.16) | 1.44 (0.30) | 1.55 (0.35) | 1.35 (0.29) | 1.46 (0.34) |
| [18F]GTP1-PET Braak56 SUVR | 1.00 (0.06) | 1.15 (0.06) | 1.13 (0.09) | 1.29 (0.26) | 1.4 (0.46) | 1.14 (0.19) | 1.25 (0.25) |
| Amyloid centiloid | –3.47 (8.98) | 38.18 (17.53) | 79.58 (38.31) | 82.71 (32.89) | 90.63 (24.61) | 70.25 (41.03) | 63.10 (35.41) |
| Elecsys pTau181 (pg/ml) | 18.07 (6.52) | 22.92 (8.78) | 32.8 (18.24) | 32.7 (15.11) | 36.73 (15.54) | 34.74 (21.2) | 36.22 (23.75) |
| Elecsys tTau (pg/ml) | 217.02 | 261.54 | 317.28 | 326.48 | 359.21 | 331.33 | 354.1 |
| (77.36) | (82.36) | (140.77) | (118.16) | (117.92) | (168.76) | (199.17) | |
| Elecsys pTau181 (pT181/tTau) | 0.083 (0.005) | 0.086 (0.008) | 0.099 (0.011) | 0.098 (0.01) | 0.1 (0.011) | 0.1 (0.014) | 0.098 (0.014) |
| pT111 (ptau/utau) | 0.039 (0.015) | 0.065 (0.028) | 0.119 (0.044) | 0.111 (0.034) | 0.137 (0.020) | 0.087 (0.035) | 0.09 (0.035) |
| pT153 (ptau/utau) | 0.002 (0.000) | 0.003 (0.002) | 0.009 (0.003) | 0.009 (0.004) | 0.009 (0.004) | 0.007 (0.003) | 0.007 (0.003) |
| pT175 (ptau/utau) | 0.003 (0.001) | 0.003 (0.001) | 0.003 (0.001) | 0.003 (0.000) | 0.002 (0.001) | 0.003 (0.001) | 0.003 (0.001) |
| pT181 (ptau/utau) | 0.237 (0.025) | 0.300 (0.027) | 0.347 (0.059) | 0.308 (0.047) | 0.28 (0.048) | 0.329 (0.058) | 0.317 (0.061) |
| pS199 (ptau/utau) | 0.003 (0.001) | 0.003 (0.001) | 0.004 (0.001) | 0.004 (0.002) | 0.004 (0.001) | 0.005 (0.002) | 0.005 (0.001) |
| pS202 (ptau/utau) | 0.039 (0.005) | 0.045 (0.016) | 0.039 (0.008) | 0.039 (0.011) | 0.034 (0.005) | 0. (0.011) | 0.037 (0.013) |
| pT205 (ptau/utau) | 0.004 (0.001) | 0.005 (0.002) | 0.006 (0.002) | 0.008 (0.002) | 0.007 (0.001) | 0.007 (0.002) | 0.007 (0.002) |
| pS208 (ptau/utau) | 0.000 (0.000) | 0.001 (0.000) | 0.001 (0.000) | 0.001 (0.000) | 0.001 (0.000) | 0.001 (0) | 0.001 (0) |
| pS214 (ptau/utau) | 0.000 (0.000) | 0.001 (0.000) | 0.001 (0.000) | 0.001 (0.000) | 0.001 (0.000) | 0.001 (0) | 0.001 (0) |
| pT217 (ptau/utau) | 0.015 (0.003) | 0.026 (0.011) | 0.061 (0.019) | 0.063 (0.020) | 0.068 (0.017) | 0.053 (0.026) | 0.059 (0.025) |
| pT231 (ptau/utau) | 0.050 (0.013) | 0.081 (0.046) | 0.203 (0.069) | 0.147 (0.061) | 0.151 (0.051) | 0.146 (0.065) | 0.157 (0.055) |
AD, Alzheimer’s disease; CN, cognitively normal; MMSE; Mini-Mental State Examination; CDRSB; Clinical Dementia Rating Sum of Boxes; ADAS13, Alzheimer’s Disease Assessment Scale; RBANS, Repeatable Battery for the Assessment of Neuropsychological Status; PET, positron emission tomography; ROI, region of interest; SUVR, standardized uptake value ratio. Elecsys pTau181 (pTau181/tTau): ratio of Elecsys pTau181/tTau; LC/MS measures pT/SXXX (ptau/utau): ratio phosphorylated peptide/unphosphorylated peptide.