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. Author manuscript; available in PMC: 2022 Feb 14.
Published in final edited form as: Environ Int. 2021 Jun 17;156:106714. doi: 10.1016/j.envint.2021.106714

Figure 3.

Figure 3.

Multiple metal linear regression analyses illustrating interactions between metal mixture components with respective birth measurements (estimates and 95% confidence intervals, gray dashed line at the null) in Project viva in sex-combined and sex-stratified analyses. The plot illustrates the marginal effect for an IQR increase in A) As on birth weight at quartiles of Mn; B-C) Mn and Zn on birth length at quartiles of Hg, respectively; D) Pb on head circumference at quartiles of Zn; E) Pb on gestational age at quartiles of Zn; and F) As on gestational age at quartiles of Pb and Mn. All six metals (As, Cd, Mn, Pb, Zn, and Hg) were included in the same model along with their two- or three-way interactions. Models were adjusted for gestational age (except when gestational age is an outcome) and potential confounders. The sex-combined analysis was also adjusted for infant sex.