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. 2022 Feb 14;22:80. doi: 10.1186/s12935-022-02483-4

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© The Author(s) 2022

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 3 — GSDM genes expression involving widely in cancer-related pathways and drug resistance. A Heatmap showing correlation between GSDM genes expression and 10 cancer related pathways. PI3K/AKT, TSC/mTOR and RTK were excluded for they significantly (FDR < = 0.05) correlated with GSDM genes in no more than 4 of 33 cancer types. Each pathway (activate or inhibit) was represented as a column and each GSDM gene was represented as a row. B Heatmap showing correlation between expression of GSDM genes and drug sensitivity. Each drug was represented as a column and each GSDM gene was represented as a row. Notice that Pearson's correlation coefficient was ranked by GSDME. C Scatter Plot showing the correlation between GSDM genes expression (in horizontal axis) and drug sensitivity (in vertical axis). Only the 15 with the smallest P values were shown. D Protein–protein interaction (PPI) network analysis of GSDM genes. The interaction was downloaded from BioGRID and visualized by Cytoscape software