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. 2022 Feb 14;22:80. doi: 10.1186/s12935-022-02483-4

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© The Author(s) 2022

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 7 — The expression of GSDME was correlated with Micro Vessel density (MVD) and GSDME promoted the invasive and migratory abilities of colon cancer cells in vitro. A The GSDME was overexpressed in HCT116 and SW480 cells. B Transwell assays in control and GSDME-overexpression SW480 cells. C Transwell assays in control and GSDME-overexpression HCT116 cells. D Migration of control or GSDME-overexpression HCT-116 and SW480 cells were determined by wounding-healing assay. E The MVD was positively correlated with GSDME expression in CRC tissue. All data were presented as the mean ± SD from three independent experiments. *P < 0.05, ** P < 0.01, ***P < 0.001