FIGURE 2.

Central administration of an oxytocin receptor antagonist does not rescue reduced contextual or cued fear responses in CD mice. (A) Schematic of the experiment. Gray boxes show rest days. Syringes indicate ICV infusions of OTA or vehicle, which occurred at least 1 hour prior to testing. (B) Day 1 of conditioned fear. CD and WT mice show increased freezing with subsequent footshock deliveries. WT OTA‐treated mice freeze significantly more than CD OTA‐treated mice. (C) Day 2. All mice show increased freezing to context (minutes 1 and 2) relative to Day 1 baseline. CD mice freeze less than WT mice but there is no main or interaction effect of treatment. (D) Day 3. CD mice have significantly decreased freezing relative to WT during minute 4 of tone delivery (p = 0.008), but there is no effect of treatment. WT Veh: n = 16; WT OTA: n = 13; CD Veh: n = 7; CD OTA: n = 7. Connected data points are means ± SEM. Individual scores are represented by smaller unconnected circles. OTA, oxytocin receptor antagonist; Veh, vehicle