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. Author manuscript; available in PMC: 2022 Feb 14.
Published in final edited form as: Annu Rev Pathol. 2021 Nov 1;17:251–269. doi: 10.1146/annurev-pathol-042320-121247

Figure 2.

Figure 2

The mechanisms of hepatic cystogenesis: a sequence of the interconnected molecular and cellular (a) primary, (b) secondary, and (c) tertiary events in cholangiocytes. In panel a, PLD-associated genes are shown in blue and respective protein products are shown in black. Abbreviations: ADPKD, autosomal dominant polycystic kidney disease; ADPLD, autosomal dominant polycystic liver disease; ARPKD, autosomal recessive polycystic kidney disease; PLD, polycystic liver disease; PLDC, polycystic liver disease cholangiocyte.