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. 2022 Feb 14;21:51. doi: 10.1186/s12943-022-01521-z

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© The Author(s) 2022

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 3 — METTL14 acted by m⁶A-dependent modification of circORC5. A MeRIP analysis of the effects of METTL14 knockdown on total m⁶A levels in MGC-803 and AGS cells. B, C Volcano plots and cluster mapping of the differential circRNAs in m⁶A levels by m⁶A-circRNA epitranscriptomic microarray. D MeRIP analysis of the m⁶A levels of circORC5, circ_0030632 an circ_0047481 in METTL14-knockdown MGC-803 and AGS cells. E RT-qPCR analysis of circORC5 expression in METTL14-knockdown MGC-803 and AGS cells. F Colony formation and G Transwell invasion assay were used to assess the effects of transfection with si-circORC5 and (or) si-METTL14 on cell proliferation and invasion in MGC-803 and AGS cells. Data are the means ± SEM of three experiments. *P < 0.05; **P < 0.01