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. 2022 Feb 14;20:88. doi: 10.1186/s12967-022-03282-1

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© The Author(s) 2022

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 2 — POR rs10954732 polymorphisms related to decreased HCC susceptibility and increased OS of HCC patients as well as enzyme activity for CYP2E1 in healthy subjects and HCC patients. a Univariate logistic regression analysis of the association between rs10954732 polymorphisms and the risk of HCC. b Kaplan–Meier curve for overall survival (OS) of HCC patients between the GG genotype and GA + AA genotypes in HCC patients. Biochemical data (c) and CYP2E1 activity (d) in subjects between GG genotype and A allele carriers in healthy subjects and HCC patients. A allele carriers, GA + AA genotypes. Normal, healthy subjects. HCC, hepatocellular carcinoma. AST transaminase, ALT alanine aminotransferase, V_max maximum reaction velocity, CL_int intrinsic clearance. Data are expressed as mean ± SEM, P value was calculated by Mann–Whitney U test