Table 2.

Resolving mediators, receptors, and their athero-relevant downstream effects.

Receptor	Ligands	Athero-relevant downstream effects	References
ALX/FPR2	Annexin A1 (Ac2-26)	↑ efferocytosis, neutrophil apoptosis	30, 46, 152-156
		↓ PMN infiltration to tissue
	AT-LXA4	↑ efferocytosis	157
	LXA4	↑ efferocytosis, anti-inflammatory cytokine production	158-161
		↓ PMN infiltration to tissue, pro-inflammatory cytokine production
	RvD1	↑ efferocytosis, anti-inflammatory cytokine production	28, 162-165
		↓ PMN infiltration to tissue, pro-inflammatory cytokine production
	RvD3	↓ PMN infiltration to tissue, pro-inflammatory cytokine production	166
	SAA	↑ leukocyte chemotaxis, pro-inflammatory cytokine production	26, 167
BLT1	LTB4 (agonist)	↑ leukocyte chemotaxis, foam cell formation	32
	RvE1 (antagonist)	↓ PMN infiltration to tissue, NF-κB activation, platelet aggregation, LTB4-induced calcium mobilization	168-170
	RvE2 (antagonist)	↑ phagocytosis	168, 171
		↓ PMN chemotaxis/infiltration to tissue
ChemR23/ERV	RvE1	↑ phagocytosis	168, 169, 172, 173
		↓ PMN chemotaxis/infiltration to tissue, pro-inflammatory cytokine production
	RvE2 (partial agonist)	↑ phagocytosis	170, 171
		↓ PMN chemotaxis/infiltration to tissue
	Chemerin	↑ adhesion and chemotaxis of leukocytes	174, 35
		↓ pro-inflammatory cytokines
		↑ apoptosis
FPR1	Annexin A1 (Ac2-26)	↓ PMN chemotaxis/infiltration to tissue, leukocyte:endothelial cell interaction	154, 175, 176
GPR18/DRV2	RvD2	↑ efferocytosis	165, 177-179
		↓ PMN infiltration to tissue, pro-inflammatory cytokine production, leukocyte:endothelial cell interaction, leukocyte activation
GPR32/DRV1	AT-RvD1	↑ phagocytosis, 12/15-LOX expression	36
		↓ oxLDL uptake
	LXA4	↑ efferocytosis, anti-inflammatory cytokine production	158-161
		↓ PMN infiltration to tissue, pro-inflammatory cytokine production
	RvD1	↑ efferocytosis, anti-inflammatory cytokine production	28, 162-164
		↓ PMN infiltration to tissue, pro-inflammatory cytokine production
	RvD3	↑ efferocytosis	166
	RvD5	↑ phagocytosis, ↓ pro-inflammatory cytokine production	180

Modified from Kasikara, Doran, et al.¹⁵