A) Body weight change (%), B) average daily food consumption (g/mouse/day), C) representative H&E and trichrome-stained liver sections and F4/80-stained adipose tissue sections with associated quantification, D) hepatic triglyceride content (mg trig per gram liver), and E) plasma ALT level (U/L) in C57BL/6J mice fed a HFHS diet for 16 weeks or a HFHS diet for 8 weeks followed by a HFHS diet supplemented with TM5441 for an additional 8 weeks (HFHS+TM). Values expressed as mean (n=8) ± SD, *p<0.05.