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. Author manuscript; available in PMC: 2022 Apr 1.
Published in final edited form as: Obesity (Silver Spring). 2021 Feb 16;29(4):713–720. doi: 10.1002/oby.23112

Figure 4: TM5441 accelerates the reversal of NAFLD in conjunction with dietary modification in mice.

Figure 4:

A) Representative H&E stained liver section, B) hepatic triglyceride content (mg trig per gram liver) in C57BL/6J mice fed a high-fat, high-sugar diet for 8 weeks (HFHS) then either a low-fat diet (LFD) or low-fat diet supplemented with TM5441 (LFD+TM) for an additional 2, 4, or 8 weeks (i.e. week 10, 12, or 16, respectively), C) hepatic mRNA expression of fatty acid oxidation genes, D) Plasma ALT (IU/L) and E) hepatic mRNA expression of pro-inflammatory genes in C57BL/6J mice fed a HFHS diet for 8 weeks then either LFD or LFD+TM for an additional 2 weeks. Values are expressed as mean (n=6) ± SD, * p<0.05.