Table 4.

Differentially expressed genes in the 2Mb local ancestry region.

Cluster	Cell Type	Gene	Fold Change	adj-p-value
2	Astrocytes	CALM3	−1.30	1.97E-108
2		APOE	−1.50	6.76E-93
2		MARK4	1.22	2.94E-66
2		HIF3A	−1.20	3.50E-62
16	Endothelial cells	APOE	−1.64	1.22E-11
23		APOE	−1.54	5.31E-07
1	Excitatory Neurons	APOE	−1.24	1.70E-162
1		CALM3	−1.27	4.66E-134
3		APOE	−1.80	1.95E-13
7		APOE	−1.22	2.53E-59
7		CALM3	−1.31	1.70E-45
8		CALM3	−1.34	1.70E-94
8		APOE	−1.27	2.50E-74
13		APOE	−1.23	5.33E-23
13		CALM3	−1.32	1.85E-12
14		CALM3	−1.51	8.38E-61
14		APOE	−1.23	3.21E-33
17		PNMA8A	−1.25	1.30E-19
17		APOE	−1.22	1.92E-19
17		CALM3	−1.38	1.80E-18
21		APOE	−1.21	2.67E-19
21		CALM3	−1.20	0.00683
22		APOE	−1.21	8.54E-12
22		CALM3	−1.22	5.85E-05
24		CALM3	−1.38	6.90E-11
27		CALM3	−1.27	0.00283
9	Inhibitory Neurons	APOE	−1.34	5.73E-39
9		CALM3	−1.26	4.06E-38
11		APOE	−1.36	2.14E-39
11		CALM3	−1.24	1.45E-16
11		ERCC1	1.25	4.00E-11
12		APOE	−1.31	3.69E-27
12		ERCC1	1.35	7.34E-19
12		CALM3	−1.20	5.33E-15
15		CALM3	−1.37	3.40E-27
15		APOE	−1.48	1.10E-25
15		PNMA8A	−1.19	3.88E-19
18		APOE	−1.33	2.40E-17
18		ERCC1	1.31	2.78E-09
26		MARK4	1.21	6.38E-05
26		CALM3	−1.26	0.00018
26		APOE	−1.20	0.00049
29		CALM3	−1.38	0.01493
29		APOE	−1.37	0.02575
4	Microglia	APOE	−2.16	2.53E-76
4		CALM3	−1.22	2.48E-17
4		PLAUR	1.24	6.99E-13
0	Oligodendrocytes	APOE	−1.31	1.18E-128
0		CALM3	−1.30	3.33E-105
5		APOE	−1.31	7.31E-29
5		CALM3	−1.29	2.71E-19
6	OPC	HIF3A	−1.25	4.31E-36
6		CALM3	−1.25	3.38E-33
6		APOE	−1.26	4.98E-25
19	VLMC	CALM3	−1.45	0.00652
19		APOE	−1.28	0.03287