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The results of PICRUst based on closed-reference OTU to predict the abundances of functional categories COG orthologs (COs) and KEGG orthologs (KOs). Panels (A,C) shows the KOs with significantly different abundances in the fecal microbiome between the CHF group and healthy control group; (B,D) shows the COs with significantly different abundances in the fecal microbiome between the CHF group and healthy control group. HF, CHF group; CON, the healthy control group.
