Appendix 2—table 1. Post-hoc analyses of age and sex.

	Original analysis		Original analysis +age and sex		Age and sex only
	X 2	p-Value	X2	p-Value	X 2	p-Value
Putamen
Patients vs. controlsRight tremor-dominant Parkinson’s disease	27.17	0.007	27.21	0.018	0.48	0.786
UPDRS symptom severityRight tremor-dominant Parkinson’s disease	22.28	0.035	23.46	0.053	2.38	0.305
L-DOPA-placebo differenceLeft tremor-dominant Parkinson’s disease	34.07	0.001	46.14	<0.001	2.42	0.299
L-DOPA-placebo differenceRight tremor-dominant Parkinson’s disease	25.48	0.012	37.53	0.001	7.18	0.028
Caudate-NAcc
Tobacco useHCP dataset	49.55	0.002	53.56	0.001	1.04	0.594
Alcohol useHCP dataset	64.45	<0.001	174.87	<0.001	9.26	0.010

UPDRS = Unified Parkinson’s Disease Rating Scale; L-DOPA = levodopa-benserazide; HCP = Human Connectome Project; NAcc = nucleus accumbens.