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Concentrations required for 50% inhibition of cell viability (IC50) of compound 5c compared to roscovitine.
| Panel/cell line | IC50 (µM)±SD* |
|||
|---|---|---|---|---|
| 5c | 8a | Roscovitine | ||
| Melanoma | MDA-MB-435 | 3.03 ± 0.38 | 6.22 ± 0.53 | 5.26 ± 0.34 |
| Glioblastoma | SNB-75 | 8.62 ± 0.13 | – | 7.76 ± 0.23 |
– means not determined.
*All results were found to be statistically significant at p < 0.05.
