Table 2. Risk of psychiatric emergency associated with antidepressant discontinuation in propensity score–matched cohort analyses^a.

Matched groups according to the time of discontinuation of the exposed group	Antidepressant discontinuation group				Antidepressant continuation group				Unadjusted HRs (95% CI)	Adjusted HRs (95% CI)b	p-Values for adjusted analyses
	No. of women	No. of events	Person-years	Incidence/1,000 person-years	No. of women	No. of events	Person-years	Incidence/1,000 person-years
Antidepressant discontinuation prior to pregnancy	2,669	76	3,309.28	23.0	2,669	91	3,258.89	27.9	0.84 (0.62 to 1.15)	0.84 (0.61 to 1.16)	0.298
During pregnancy	2,669	40	2,002.38	20.0	2,669	52	1,959.36	26.5	0.75 (0.50 to 1.14)	0.74 (0.47 to 1.15)	0.175
Within 6 months postpartum	2,578	36	1,281.34	28.1	2,578	38	1,280.20	29.7	0.97 (0.61 to 1.56)	0.98 (0.60 to 1.60)	0.946
Antidepressant discontinuation during pregnancy	5,467	202	5,335.86	37.9	5,467	156	5,312.48	29.4	1.29 (1.05 to 1.59)	1.25 (1.00 to 1.55)	0.048
During pregnancy	5,467	92	2,677.95	34.4	5,467	58	2,632.62	22.0	1.59 (1.14 to 2.20)	1.52 (1.08 to 2.15)	0.016
Within 6 months postpartum	5,316	106	2,630.23	40.3	5,316	98	2,635.26	37.2	1.15 (0.85 to 1.54)	1.09 (0.80 to 1.47)	0.596

^aThe numbers of cases of psychiatric emergency occurred during pregnancy and within 6 months postpartum do not add up to the whole period since only matched individuals contribute to the analyses.

^bAdjustment for imbalanced variables: level of education status and the use of TCAs or MAOIs in the 90 days before pregnancy for the estimate of antidepressant discontinuation before pregnancy and the level of education and age at first affective disorder for the estimate of antidepressant discontinuation during pregnancy.

CI, confidence interval; HR, hazard ratio; MAOI, monoamine oxidase inhibitor; TCA, tricyclic antidepressant.