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. 2022 Feb 7;27(1):32–44. doi: 10.1080/13510002.2022.2036507

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© 2022 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 8. — PM2.5 triggers mitophagy and activates mitochondria-related apoptosis signal Bax/Bcl-2. (A) GFP-LC3 adenovirus and Mito tracker Red were used to label autophagosomes and mitochondria in HaCaT cells to detect the process of mitochondrial autophagy (mitophagy). Scale bar = 10 μm. (B) Mitochondrial membrane potential was evaluated by JC-1 assay. Scale bar = 50 μm. (C) HaCaT cells were pretreated with 3-MA or LBP and then exposed to PM2.5 for 24 h. The expression levels of Bax and Bcl-2 was analyzed by Western blot assay. Values are mean ± SD. *p < 0.05 versus the control group; #p < 0.05 versus the PM2.5 treatment alone group.