(A) Representative image showing body condition of a WT and TRAF6[L74H] mouse. (B) Graphs show thickness of the left and right ears of WT (n = 3) and TRAF6[L74H] (n = 6) mice. (C) Cumulative body scores based on skin thickening, ear position, hair loss around the eyes, skin scaling, hunched position, piloerection and face grimace in 16 days old WT (n = 20) and TRAF6[L74H] (n = 24) mice. Symbols represent individual biological replicates. Statistical significance between the two genotypes was calculated using the Mann-Whitney test; * denotes p<0.05 and *** denotes p<0.001. Individual values, descriptive statistics and results from the statistical analysis are provided in S3 File.