TABLE 2.
Continuous Infusion Ketamine Dose and Administration (n = 390)
| Dose Information | Value |
|---|---|
| Loading dose | |
| Dose, mg/kg, median (IQR), n = 99 | 0.9 (0.4–1.0) |
| Weight, kg, median (IQR) | 82.7 (70.0–101.1) |
| Weight used, n (%) | |
| Actual | 80 (80.8) |
| Estimated | 12 (12.1) |
| Ideal | 4 (4.0) |
| Adjusted | 3 (3.0) |
| Continuous infusion | |
| Initial units, n (%) | |
| µg/kg/min | 234 (60.0) |
| mg/kg/hr | 132 (33.9) |
| mg/hr | 24 (6.1) |
| Initial dosea, median (IQR) | |
| Overall | 0.2 (0.1–0.5) |
| Analgesia | 0.15 (0.09–0.3) |
| Analgosedation | 0.2 (0.12–0.3) |
| Sedation | 0.3 (0.12–0.5) |
| Alcohol withdrawal | 1.2 (1.1–1.25) |
| Bronchodilation | 0.5 (0.08–0.9) |
| Status epilepticus | 0.55 (0.3–1) |
| Weight, kg, median (IQR), n = 366 | 81.6 (68.0–98.5) |
| Weight used, n (%) | |
| Actual | 300 (82.0) |
| Ideal | 38 (10.4) |
| Estimated | 18 (4.9) |
| Adjusted | 10 (2.7) |
| Ketamine titratable dose | |
| Ketamine—titratable CI, n (%) | 228 (58.5) |
| Initial rate, dose, median (IQR) | |
| µg/kg/min (n = 176) | 2.5 (1.4–5.0) |
| mg/kg/hr (n = 41) | 0.2 (0.1–0.5) |
| mg/hr (n = 9) | 10.0 (10.0–25.0) |
| Unknown (n = 2) | — b |
| Dose increments, median (IQR), n = 228 | |
| µg/kg/min (n = 67) | 1 (1–5) |
| mg/kg/hr (n = 39) | 0.1 (0.1–0.2) |
| mg/hr (n = 8) | 5 (5–20) |
| Unknown (n = 114) | — b |
| Titration endpoints, n (%), n = 228 | |
| Sedation score | 128 (56.1) |
| Pain score | 56 (24.6) |
| Burst suppression/seizures | 3 (1.3) |
| Incentive spirometry | 2 (0.9) |
| Wheezing | 1 (0.4) |
| Blood pressure | 1 (0.4) |
| Unknown | 55 (24.1) |
| Ketamine fixed dose | |
| Ketamine—fixed-rate CI, n (%) | 162 (41.5) |
| Initial rate, dose, median (IQR) | |
| µg/kg/min (n = 57) | 3.0 (1.8–5.5) |
| mg/kg/hr (n = 91) | 0.5 (0.2–1.0) |
| mg/hr (n = 14) | 25.0 (25.0–33.0) |
CI = continuous infusion, IQR = interquartile range.
aAll doses converted to mg/kg/hr.
bUnable to determine value.