Figure 3. Loss of KRAS^G12C variants and clonal phylogenetic analyses.

(A) Total number of mutations detected in each tumor sample. A 2-sided Student’s t test was run to compare mean numbers of single nucleotide variants between pre- and post-AMG510 treatment. (B) KRAS^G12C mutation allele frequency detected in each sample. Sequenza purity levels are shown for each sample in black. (C) Nonsynonymous mutations detected in 3 or more tumors with mutations expressed in RNA. (D) Representative phylogenetic trees showing potential clonal evolution. Pre- and posttreatment samples are colored in the branches as purple and green, respectively.