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. 2022 Feb 9;17:603–616. doi: 10.2147/IJN.S347506

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© 2022 Wei et al.

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Oral administration of HA NPs and HA-PS@NPs yields an enhanced therapeutic efficacy against DSS-induced UC. (A) Schematic illustration of the murine model of colitis induced by 2% DSS along with NPs treatment at 500 mg/kg (PS 40mg/kg) for consecutive 7 days. Mice were orally administrated with hydrogel or hydrogel encapsulated of HA NPs and HA-PS@NPs every other day. The daily changes in body weight (n=6) (B) and disease activity index (DAI) (C) of the mice during a 7-day treatment course. (D) Colon length change of different treatment groups (n=6). (E) HA-PS@NPs significantly reduces epithelial permeability in UC. The mice were gavaged with FITC-dextran (40 mg/100 g body weight) and blood was collected 5 hours later. The serum concentration of FITC-dextran was quantified by a fluorescence Spectrometer (485/528 nm) (n=5), *p<0.05, **p<0.01, ***p<0.01. (F–I) The mRNA expression levels of TNF-α, IL-1β, IL-6, IL-12 (n=6). *p<0.05, ***p<0.01. (J) Hematoxylin and eosin staining for microscopic evaluation of the colon sections isolated from healthy control, DSS, HA NPs and HA-PS@NPs treated groups. Images of tissues are shown with 4× and 100× magnification, (n=10/group). Arrowheads indicate inflammatory cells in the lamina propria. (K) Histological scores from the different treatment groups were calculated (n=6). ***p<0.001.