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. Author manuscript; available in PMC: 2023 Mar 1.
Published in final edited form as: Neuropharmacology. 2021 Dec 9;205:108916. doi: 10.1016/j.neuropharm.2021.108916

Figure 6. M1Rs and mGlu1/5s trigger 2-AG mobilization through distinct mechanisms that differentially require ionotropic glutamate receptors.

Figure 6.

A) Timecourse of the M1R PAM, VU’846, on the amplitude of 2-AG transients in the presence of the AMPAR antagonist, DNQX. 2-AG transients were evoked by a 5 pulse train at 20Hz (5p 20Hz). Gray shading indicates drug application periods. B) Effect of DNQX and DNQX+VU’846 at the end of each drug application period. C) Representative 2-AG transients at baseline, after DNQX and after DNQX+VU’846. D-F) Same as above except VU’846 was bath applied in the presence of the NMDA receptor antagonist, DL-AP5. G-I) Same as A-C except the mGlu1/5 agonist, DHPG, was bath applied in the presence of DNQX. *, p < 0.05; **, p < 0.01; ***, p < 0.001; ****, p < 0.0001.