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. 2020 Dec 2;9(2):325–333. doi: 10.1016/j.gendis.2020.11.016

Figure 2.

Figure 2

LncRNA CASC11 facilitated tumor progression via sponging miRNAs in cancers. (A) Ovarian cancer: CASC11 overexpression induces the expression of miR-182 and promotes the proliferation of OC cells. (B) Neuroblastoma: CASC11 promotes the malignant transformation of NB mediated by NOL4L. (C) Bladder cancer: overexpression of CASC11 enhances the invasiveness of BC cells mediated by miR-150 down-regulation. (D) Gastric cancer: CASC11 induces the expression of CDK1 mediated by the inactivation of miR-340-5p. (E) Glioma: CASC11 promotes glioma migration mediated by the down-regulated miR-498 as well as the activation of FOXK1. (F) Lung cancer: CASC11 promotes tumorigenesis of LC by upregulating CDK1 expression mediated by miRNA-302. (G) Hepatocellular carcinoma: CASC11 may promote tumorigenesis of HCC by inhibiting miR-188-5p. Abbreviations: NOL4L: Nucleolar protein 4 like; CDK1: Cyclin-dependent kinase 1; FOXK1: Forkhead Box K1.