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. 2020 Aug 31;9(2):429–442. doi: 10.1016/j.gendis.2020.08.009

Figure 2.

Figure 2

Ccrl2 deficiency mice showed aggravated obesity and insulin resistance on ND. (A) Gene sequencing results of knock out (one base knockout). (B) Body weight gain of Littermates ccrl2+/−ccrl2−/− mice fed with normal diet (n = 7, 10, 10). (C) core temperature of ND fed WT ccrl2+/−ccrl2−/− mice. (D) ratio of VAT/SAT to body weight in Littermates ccrl2+/−ccrl2−/− mice (n = 7, 10, 10). (E) HE and line length statistics of VAT and SAT, scale bar = 100 mm. (F) GTT (n = 7, 10, 10). (G) ITT (n = 7, 10, 10). Data are expressed as Mean ± SEM, ns = not significant, ∗P < 0.05, ∗∗P < 0.01, ∗∗∗P < 0.001.