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. 2021 Nov 12;13:135–148. doi: 10.1016/j.bioactmat.2021.11.009

Fig. 6.

Fig. 6

The brain can be explained from various perspectives using the physiome. These brain features viewed from various perspectives can be reproduced on high-technology in vitro platforms, brain organoids, or brain-on-a-chip. Furthermore, by providing data about various drug side effects, obtained from high-technology in vitro platforms, to an in silico tool, it will be possible to conduct high-throughput discovery of drug side effects and reduce laboratory animals' sacrifice.