Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2022 Feb 1;12:792293. doi: 10.3389/fphar.2021.792293

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

Copyright © 2022 Li, Wang, Zeng, Guo, Xu, Li, Lai, Ye and Peng.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

PMC Copyright notice

Depletion of wt-p53 increases prostate cancer cells chemotaxis to osteoblasts. (A) Representative images (left panel) and quantification (right panel) of wound-healing assays for the indicated cell lines. Wound closure was photographed at 24 h after wounding. Prostate cancer cells were cultured in MC3T3-E1 condition medium (CM). (B) Representative micrographs (left panel) and quantification (right panel) of the migration of indicated cells in transwell assays. Co-culture, tumor cells (top chamber) were co-cultured with primary osteoblasts (bottom chamber) in the transwell plate. (C) Representative images (left panel) and quantification (right panel) of in vitro competitive colocalization assays for the indicated cells by confocal microscopy. Error bars represent the means ± SD of 3 independent experiments. *p < 0.05, **p < 0.01, ***p < 0.001, n. s., no significance. Original magnification, A, ×100; B, ×200; C, ×400.