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. 2022 Feb 1;12:804265. doi: 10.3389/fphar.2021.804265

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Copyright © 2022 Li, Zheng, Cheng, Li, Mai, Jiang, Yang, Zhang, Li, Zheng, Wang and Qi.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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DUb inhibits the colony formation, migration and invasion of LoVo cells throuth upregulating SIRT2. (A) DUb did not change SIRT2 expression in SIRT2-silenced LoVo cells (n = 3). (B) DUb did not affect the ability of LoVo cells to form colonies after SIRT2 was silenced (n = 4). (C) DUb did not affect the ability of LoVo cells to migrate (n = 6) and invade (n = 6) after SIRT2 was silenced. Data are presented for at least three independent experiments. Scale bar = 100 µm in C. *p < 0.05; ***p < 0.001.