Table 3:

Biomarker true positive rate (and 95% confidence interval) with screening-level false positive rate fixed at 10%

	Any Stage HCC			Early-Stage HCC
	Any time prior to HCC	0-6 months prior to HCC	7-12 months prior to HCC diagnosis	Any time prior to HCC	0-6 months prior to HCC	7-12 months prior to HCC diagnosis
GALAD −0.33	54.8 (39.5-70.2)	72.0 (52.6-88.9)	50.0 (23.1-73.7)	53.8 (33.3-73.3)	73.7 (52.0-93.3)	44.4 (10.0-80.0)
Longitudinal GALAD	66.7 (51.3-80.8)	64.0 (42.9-83.3)	62.5 (35.3-85.7)	69.2 (50.0-86.4)	68.4 (44.4-88.9)	66.7 (28.6-100.0)
HES Algorithm 10.05	45.2 (26.1-62.1)	44.0 (21.1-62.5)	43.8 (20.0-72.2)	34.6 (14.3-56.5)	42.1 (18.2-66.7)	22.2 (0-60.0)
AFP 17.4 ng/mL	40.5 (24.2-57.1)	52.0 (30.4-75.0)	18.8 (0.0-42.9)	50.0 (28.0-69.0)	63.2 (35.3-85.7)	22.2 (0-57.1)
AFP-L3% 11.9%	45.2 (30.2-68.8)	43.8 (33.3-80.8)	43.8 (21.0-72.7)	46.2 (25.0-73.5)	33.3 (25.0-82.4)	33.3 (0-75.0)
DCP 5.9 ng/mL	26.2 (13.0-42.9)	20.0 (5.0-38.1)	37.5 (13.3-64.3)	34.6 (15.4-52.6)	26.3 (6.7-48.5)	55.6 (14.3-87.5)