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. 2022 Feb 14;13(2):149. doi: 10.1038/s41419-022-04604-3

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 2 — A Gene ontology analysis of the RNA sequencing data shows that RNF187 depletion in breast cancer cells activates the apoptotic process and cell cycle arrest. MCF-7 cells were transfected with siRNF187 or siControl. After 48 h, total mRNA was extracted for RNA sequencing analysis. The siControl and siRNF187 groups were analyzed in triplicate. B The heat map shows the P53 target genes, whose expression is significantly increased by RNF187 depletion in MCF-7 cells. C–E Publicly available data show that RNF187 expression is inversely correlated with that of the p53 target genes IGFBP3, MDM2, and FAS (https://tcga-data.nci.nih.gov/tcga/). F, G The Kaplan–Meier curve of progression-free survival shows that RNF187 tends to be related to poor prognosis in breast cancer patients harboring wild-type P53, but no correlation was found in the P53 mutant groups. The data were generated from the KMPLOT database (https://kmplot.com). H, I The Kaplan–Meier curve of overall survival shows that RNF187 correlates with poor survival in a luminal-type of breast cancer patients harboring wild-type P53, but no correlation was found in the P53 mutant groups of luminal-type breast cancers. The data were generated from the TCGA database (https://tcga-data.nci.nih.gov/tcga/).