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. 2022 Feb 14;7:48. doi: 10.1038/s41392-022-00904-4

Fig. 11.

Fig. 11

Mechanisms of GLP-1 and GLP-1RA peptide drugs in regulation of T2DM. GLP-1 and GLP-1RA peptide drugs treat T2DM by regulating multiple organs functions, such as reducing gastric emptying and gastric acid secretion, reducing appetite, promoting cardiac glucose utilization, accelerating renal natriuresis and diuresis, minimizing glucose production in the liver and increasing insulin secretion in the pancreas