Table 3:

Estimates of the Multivariable Adjusted Association of glycemic markers and incident heart failure

	Unadjusted Hazard Ratio (95% CI)	Adjusted Hazard Ratio (95% CI)	P-value
Glycated hemoglobin (HbA 1C )
≤5.7 %	1 (Reference)	1 (Reference)
5.7 – 6.4 %	1.12 (0.72, 1.77)	0.84 (0.52, 1.33)	0.45
≥ 6.5 %	2.90 (1.88, 4.45)	1.65 (1.03, 2.62)	0.0355
1 SD increment of HbA 1C	1.38 (1.24, 1.52)	1.30 (1.12, 1.51)	0.0007
Fasting Plasma Glucose (mg/dL)
<100 mg/dL	1 (Reference)	1 (Reference)
100–125 mg/dL	1.19 (0.78, 1.81)	0.81 (0.51, 1.26)	0.34
≥ 125 mg/dL	3.13 (2.00, 4.89)	1.92 (1.20, 3.08)	0.0070
1-SD increment of fasting Glucose	1.29 (1.17, 1.42)	1.32 (1.17, 1.48)	<0.0001
Hyperglycemia status (defined by both fasting plasma glucose and HbA 1C )
Normal	1 (Reference)	1 (Reference)
Pre-diabetes	0.96 (0.58, 1.57)	0.68 (0.41, 1.13)	0.14
Diabetes	2.36 (2.03, 3.79)	1.24 (1.02, 2.05)	0.03

Values are hazard ratios (95% confidence interval [CI]) and P values. The hazard ratios are adjusted for age, sex, smoking, income, alcohol use, physical activity, body mass index, ratio of total to HDL-cholesterol, systolic blood pressure, use of antihypertensive medications, use of statins, eGFR, and CHD (time-varying covariate).