Table 1.
Effects of thyme oil and thymol oral supplementation on liver function biomarkers in serum of DOX-injected rats.
| Groups | Parameters | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| ALT (U/L) | % change | AST (U/L) | % change | ALP (U/L) | % change | Total bilirubin (mg/dl) | % change | Albumin (g/dl) | % change | |
| Normal | 49.33 ± 2.72 | — | 187.67 ± 5.98 | — | 201.33 ± 10.19 | — | 0.56 ± 0.03 | — | 3.75 ± 0.25 | — |
| DOX-injected control | 62.50 ± 2.79a | +26.70 | 212.00 ± 4.93a | +12.96 | 233.33 ± 8.13 | +15.89 | 0.70 ± 0.05a | +25.00 | 2.17 ± 0.11b | -42.13 |
| DOX-injected group treated with thyme oil | 40.00 ± 2.02b | -36.00 | 185.00 ± 7.79b | -12.74 | 173.17 ± 11.28b | -25.78 | 0.51 ± 0.04b | -27.14 | 2.42 ± 0.20a | +11.52 |
| DOX-injected group treated with thymol | 52.33 ± 5.25b | -16.27 | 189.17 ± 7.24b | -10.77 | 248.00 ± 15.56a | +6.29 | 0.57 ± 0.03b | -18.57 | 3.08 ± 0.37b | +41.94 |
| F-prob. | p < 0.01 | p < 0.05 | p < 0.001 | p < 0.05 | p < 0.01 | |||||
| LSD at the 5% level | 10.09 | 19.40 | 34.26 | 0.12 | 0.74 | |||||
| LSD at the 1% level | 13.76 | 26.46 | 46.73 | 0.16 | 1.01 | |||||
Data are represented as mean ± standard error (M ± SE) of six rats. aSignificant as compared to normal at p < 0.05. bSignificant as compared to DOX-injected control at p < 0.05. Percentage changes were computed by comparing DOX-injected group with normal and DOX-injected groups treated with thyme oil and thymol with DOX-injected control.