Table 4.
Effects of thyme oil and thymol oral supplementation on LPO and various antioxidants in the liver of DOX-injected rats.
| Groups | Parameters | |||||||
|---|---|---|---|---|---|---|---|---|
| LPO in the liver (nmole MDA/100 mg tissue/hr) | % change | Liver GSH content (nmole/100 mg tissue) | % change | Liver GST activity (mU/100 mg tissue) | % change | Liver GPx activity (U/100 mg tissue) | % change | |
| Normal | 50.04 ± 1.74 | 45.50 ± 5.00 | — | 55.73 ± 1.92a | — | 162.08 ± 2.96 | — | |
| DOX-injected control | 60.14 ± 1.28a | +20.18 | 23.74 ± 1.78a | -47.82 | 41.70 ± 1.71a | -25.17 | 140.10 ± 4.68a | -13.56 |
| DOX-injected group treated with thyme oil | 43.05 ± 3.93b | -28.42 | 37.17 ± 3.34b | +56.57 | 48.59 ± 2.07ab | +16.52 | 152.99 ± 4.25b | +9.20 |
| DOX-injected group treated with thymol | 41.54 ± 4.78b | -30.93 | 37.50 ± 3.23b | +57.96 | 51.94 ± 2.25b | +24.56 | 156.71 ± 4.56b | +11.86 |
| F-prob. | p < 0.01 | p < 0.01 | p < 0.001 | p < 0.01 | ||||
| LSD at the 5% level | 9.67 | 10.40 | 5.89 | 12.30 | ||||
| LSD at the 1% level | 13.18 | 14.18 | 8.03 | 16.77 | ||||
Data are represented as M ± SE of six rats. aSignificant as compared to normal at p < 0.05. bSignificant as compared to DOX-injected control at p < 0.05. Percentage changes were computed by comparing DOX-injected control with normal and DOX-injected groups treated with thyme oil and thymol with DOX-injected control.