Table 5.
Histological lesion scores of the liver in normal control, DOX-administered group, and DOX-administered groups supplemented with DOX-injected rats with thyme oil and thymol.
| Histological changes | Score | Normal control | DOX | DOX + thymol oil | DOX+ thymol |
|---|---|---|---|---|---|
| Thickening of the hepatic capsule | 0 | 6 (100%) | 1 (16.7%) | 6 (100%) | 4 (66.6%) |
| I | — | 1 (16.7%) | — | 2 (33.3%) | |
| II | — | 2 (33.3%) | — | — | |
| III | — | 2 (33.3%) | — | — | |
|
| |||||
| Cytoplasmic vacuolization of hepatocytes and hydropic degeneration | 0 | 6 (100%) | — | 2 (33.3%) | 2 (33.3%) |
| I | — | 1 (16.7%) | 2 (33.3%) | 1 (16.7%) | |
| II | — | 2 (33.3%) | 1 (16.7%) | 1 (16.7%) | |
| III | — | 3 (50%) | 1 (16.7%) | 2 (33.3%) | |
|
| |||||
| Fibroblastic proliferation in the portal tract and oval cell proliferation | 0 | 6 (100%) | 1 (16.7%) | 6 (100%) | 6 (100%) |
| I | — | 1 (16.7%) | — | — | |
| II | — | 2 (33.3%) | — | — | |
| III | — | 2 (33.3%) | — | — | |
|
| |||||
| Focal hepatic necrosis and inflammation | 0 | 6 (100%) | — | 6 (100%) | 5 (83.3%) |
| I | — | 2 (33.3%) | — | 1 (16.7%) | |
| II | — | 2 (33.3%) | — | — | |
| III | — | 2 (33.3%) | — | — | |
|
| |||||
| Apoptosis of hepatocytes | 0 | 5 (83.3%) | 1 (16.7%) | 5 (83.3%) | 5 (83.3%) |
| I | 1 (16.7%) | 1 (16.7%) | 1 (16.7%) | 1 (16.7%) | |
| II | — | 2 (16.7%) | — | — | |
| III | — | 2 (33.3%) | — | — | |
|
| |||||
| Fibrosis around bile duct | 0 | 6 (100%) | 1 (16.7%) | 5 (83.3%) | 4 (66.6%) |
| I | — | 2 (33.3%) | 1 (16.7%) | 2 (33.3%) | |
| II | — | 3 (50%) | — | — | |
| III | — | 1 (16.7%) | — | — | |
|
| |||||
| Appearance of newly formed bile ductules and strands of fibroblasts around the hepatocytes | 0 | 6 (100%) | — | 4 (66.6%) | 5 (83.3%) |
| I | — | 1 (16.7%) | 2 (33.3%) | 1 (16.7%) | |
| II | — | 2 (33.3%) | — | — | |
| III | — | 3 (50%) | — | — | |
0: absence of lesion; I: mild; II: moderate; III: severe. The number of animals in each group is 6. The % in parentheses is the percent of animals in each grade.