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. Author manuscript; available in PMC: 2023 Feb 28.
Published in final edited form as: J Mol Biol. 2021 Oct 13;434(4):167301. doi: 10.1016/j.jmb.2021.167301

Figure 1. Inflammasome activation and pyroptosis.

Figure 1.

Various PAMPs and DAMPs are recognized by both membrane and cytoplasmic receptors, leading to a series of signaling cascades, expression of cytokines and inflammasome sensers and adaptors, and assembly of either canonical or non-canonical inflammasome. As a result, caspases are activated and subsequently cleave gasdermins (primarily GSDMD) and pro-cytokines IL-1β and IL-18. Pore-formation and release of cytokines and tissue factor lead to cell lysis, inflammation, coagulation, and tissue damage. Created with biorender.com.