Table 1.
Findings on circulating miRNAs in adrenocortical cancer.
| Author and year of publication | Sample type | Method of miRNA isolation | Cohort | miRNAs in ACC compared to adenoma or normal adrenal cortices | Reference |
|---|---|---|---|---|---|
| Chabre et al. (2013) | Serum | qRT-PCR | 23ACC, 14ACA, 19NA | miR-483-5p↑, miR-335↓, miR-195↓, miR-139-5p↑, miR-376a↓ | (24) |
| Patel et al. (2013) | Serum | qRT-PCR | 17ACC, 22ACA | miR-483-5p↑, miR-34a↑ | (39) |
| Szabo et al. (2014) | Plasma | qRT-PCR | 13ACC, 12ACA | miR-100↑, miR-181b↑, miR-184↑, miR-210↑, miR-483-5p↑ | (40) |
| Perge et al. (2017) | Plasma-EV | qRT-PCR | 22ACC, 24ACA | miR-101↑, miR-483-5p↑ | (41) |
| Salvianti et al. (2017) | Plasma | qRT-PCR | 27ACC, 13ACA, 10NA | miR-483-5p↑ | (42) |
| Perge et al. (2018) | Plasma-EV | qRT-PCR | 9CP-ACC, 13CPA, 13NFA | miR-320b↑, miR-27a-3p↑, miR-22-3p↑, miR-210-3p↑ | (43) |
| Decmann et al. (2018) | Plasma | qRT-PCR | 11ACC, 11ACA, 11AML | miR-483-3p↑, miR-483-5p↑ | (36) |
| Decmann et al. (2019) | Plasma | qRT-PCR | 23ACC, 23ACA | miR-483-5p↑ | (44) |
↑, up-regulation; ↓, down-regulation; qRT-PCR, quantitative real-time polymerase chain reaction; ACC, adrenocortical carcinoma; ACA, adrenocortical adenoma; AML, adrenal myelolipoma; NA, normal adrenal; EV, extracellular vesicle; CP-ACC, cortisol-producing adrenocortical carcinoma; CPA, adrenocortical adenoma; NFA, non-functioning adrenocortical adenoma.