Table 2.
Diagnostic accuracy of circulating miRNA for differentiating adrenocortical carcinoma from adrenocortical adenoma.
| Author and year of publication | Tape of sample | Comparison | MiRNA | Sensitivity | Specificity | AUC | Reference |
|---|---|---|---|---|---|---|---|
| Chabre et al. (2013) | Serum | ACC-ACA | miR-195 | 90.9 | 100 | 0.948 | (24) |
| miR-335 | 95.2 | 71.4 | 0.837 | ||||
| miR-139-5p | 87.5 | 65 | 0.714 | ||||
| miR-376a | 71.4 | 85.7 | 0.811 | ||||
| aACC-naACC | miR-483-5p | 87.5 | 100 | 0.929 | |||
| Patel et al. (2013) | Serum | ACC-ACA | miR-34a | ND | ND | 0.81 | (39) |
| miR-483-5p | ND | ND | 0.74 | ||||
| Szabo et al. (2014) | Plasm | ACC-ACA | dCTmiR-210-dCT181b | 88.9 | 75 | 0.87 | (40) |
| dCTmiR-100-dCT181b | 77.8 | 100 | 0.85 | ||||
| Perge et al. (2017) | P-EV | ACC-ACA | miR-483-5p | 87.5 | 94.44 | 0.965 | (41) |
| miR-101 | 68.75 | 83.33 | 0.766 | ||||
| Salvianti et al. (2017) | Plasma | Low stages ACC-High stages ACC | miR-483 | 87.5 | 63.6 | 0.875 | (42) |
| miR-483-5p | 83.3 | 100 | 0.917 | ||||
| Perge et al. (2018) | P-EV | CP-ACC-CPA | miR-320b | 88.89 | 76.92 | 0.8632 | (43) |
| Decmann et al. (2018) | Plasma | ACC-ACA | miR-483-5p | 81.82 | 90.91 | 0.88 | (36) |
| Decmann et al. (2019) | Plasma | ACC-ACA | miR-483-5p | 87 | 78.3 | 0.88 | (44) |
miR, microRNAs; P-EV, Plasma-extracellular vesicle; AUC, area under curve; ACC, adrenocortical carcinoma; aACC, aggressive ACC; naACC, non-aggressive ACC; CP-ACC, cortisol-producing ACC; CPA, cortisol-producing ACA; Tumor stage was assessed according to the revised TNM classification of ACC, low stages(stage I-II); high stages(stage III-IV). ND, no data.