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. 2022 Feb 14;12:2458. doi: 10.1038/s41598-022-06422-1

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Graphical representation of Phage Bacteria Infection Networks (PBINs) and candidate Phage Cocktail Networks (PCNs) depicting the Minimum Cocktail Size (MCS). A total of 50 PBINs, each harboring a PCN subnetwork, were built and phage cocktails were designed using an exhaustive algorithm as detailed in Methods and sorted by increasing matrix size (Table 1). The shape of the nodes represents bacteria (), unselected phages () and cocktail phages (). The expected importance (EI) of each node represented by color shading so that more relevant nodes show more intense colors. Bacteria not susceptible to any phage (EI_b = -100) are clustered in grids. Lysis is indicated by dark (unselected phages) or orange (phage cocktail) lines.

Inline graphic — Graphical representation of Phage Bacteria Infection Networks (PBINs) and candidate Phage Cocktail Networks (PCNs) depicting the Minimum Cocktail Size (MCS). A total of 50 PBINs, each harboring a PCN subnetwork, were built and phage cocktails were designed using an exhaustive algorithm as detailed in Methods and sorted by increasing matrix size (Table 1). The shape of the nodes represents bacteria (), unselected phages () and cocktail phages (). The expected importance (EI) of each node represented by color shading so that more relevant nodes show more intense colors. Bacteria not susceptible to any phage (EI_b = -100) are clustered in grids. Lysis is indicated by dark (unselected phages) or orange (phage cocktail) lines.