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. 2022 Feb 14;12:59. doi: 10.1038/s41398-022-01817-0

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 1 — The size of the circle is proportional to the genetic correlation estimates, going from warmer to colder colours as the direction of the effect changes from positive to negative. Bonferroni multiple testing correction was applied, correcting for the number of analyses performed (α = 0.05/(9 x 9) = 6.17e−4). AD Alzheimer’s disease, ASD autism spectrum disorder, OCD obsessive-compulsive disorder, ADHD attention-deficit/hyperactivity disorder, AN anorexia nervosa, BD bipolar disorder, MDD major depressive disorder, SCZ schizophrenia, TS Tourette’s syndrome, MetS metabolic syndrome, T2DM type 2 diabetes mellitus, 2hGlu glucose levels 2 h after an oral glucose challenge, BMI body mass index, FPG fasting plasma glucose, FPI fasting plasma insulin, HbA1c glycated haemoglobin, HOMA-IR homeostatic model assessment for insulin resistance. ** Statistically significant bivariate genetic correlation (p < 6.17 × 10⁻⁴). * Nominally significant bivariate genetic correlation (p < 0.05).