Skip to main content
. 2022 Feb 14;12:59. doi: 10.1038/s41398-022-01817-0

Table 1.

Characteristics of the samples used for the Linkage-Disequilibrium SCore regression (LDSC) and GeNetic cOVariance Analyzer (GNOVA) analyses.

Trait/disorder Author Year PMID Consortium Ancestry N Cases Controls Neff
2hGlu Saxena et al. 2010 20081857 MAGIC European 15,234
BMI Pulit et al. 2019 30239722 GIANT European 697,734
FPG Lagou et al. 2021 33402679 MAGIC European 140,595
FPI Lagou et al. 2021 33402679 MAGIC European 98,210
HbA1c Wheeler et al. 2017 28898252 MAGIC European 123,665
HOMA-IR Dupuis et al. 2010 20081858 MAGIC European 37,037
MetS Lind 2019 31589552 European 291,107 59,677 231,430 189,772.64
Obesity Watanabe et al. 2019 31427789 European 244,890 9805 235,085 37,649.69
T2DM Mahajan et al. 2018 30297969 DIAGRAM European 898,130 74,124 824,006 272,025.75
ADHD Demontis et al. 2019 30478444 PGC European 53,293 19,099 34,194 49,017.41
AD Wightman et al. 2021 34493870 PGC European 762,917 86,531 676,386 306,866.18
AN Watson et al. 2019 31308545 PGC European 72,517 16,992 55,525 52,041.91
ASD Grove et al. 2019 30804558 PGC European 46,350 18,381 27,969 44,366.62
BD Mullins et al. 2021 34002096 PGC European 413,466 41,917 371,549 150,669.89
OCD OCGAS/IOCDF-GC 2018 28761083 OCGAS/IOCDF-GC European 9725 2688 7037 7780.14
MDD Wray et al./Howard et al. 2019 29700475/ 29662059 PGC European 500,199 170,756 329,443 449,855.91
SCZ Pardinas et al. 2018 29483656 PGC + CLOZUK European 105,318 40,675 64,643 99,863.42
TS Yu et al. 2019 30818990 PGC European 14,307 4819 9488 12,783.30

2hGlu glucose levels 2 h after an oral glucose challenge, BMI body mass index, FPG fasting plasma glucose, FPI fasting plasma insulin, HbA1c glycated haemoglobin, HOMA-IR homeostatic model assessment for insulin resistance, MetS metabolic syndrome, T2DM type 2 diabetes mellitus, ADHD attention-deficit/hyperactivity disorder, AD Alzheimer’s disease, AN anorexia nervosa, ASD autism spectrum disorder, BD bipolar disorder, MDD major depressive disorder, OCD obsessive-compulsive disorder, SCZ schizophrenia, TS Tourette’s syndrome, N total sample size, Neff effective sample size [Neff = 4/(1/Cases +  1/Controls)].