Table 1.
HLA class I and class II eplet mismatches.
| No. of Treg-ASC pair | HLA-A eplet mismatches (HLA-A eplet mismatch load) | HLA-B eplet mismatches (HLA-B eplet mismatch load) | HLA-C eplet mismatches (HLA-C eplet mismatch load) | HLA-DRB1 eplet mismatches (HLA-DRB1 eplet mismatch load) | HLA-DQB1 eplet mismatches (HLA-DQB1 eplet mismatch load) |
|---|---|---|---|---|---|
| 1. | 43Q + 62GER, 62GE, 62GK2, 107 W, 127 K, 144TKH, 145KHA | 41 T, 80I, 80I + 69TNT, 80I + 90 A, 82LR, 82LR + 90 A, 82LR + 138 T, 82LR + 144QR, 82LR + 145 R, 82LR + 145RA, 131 S + 163 T, 156DA, 158 T | 80 K + 14 R | 11STS, 74 R, 77 N | 45GE3, 77 R |
| (7) | (13) | (1) | (3) | (2) | |
| 2. | 62QE + 56 G, 76ESI, 82LR + 138 M | 131 S + 163 T, 158 T | 21H, 80 K, 80 K + 14 R | 74 R, 77 N | 45GE3, 77 R |
| (3) | (2) | (3) | (2) | (2) | |
| 3. | 66NV, 161D | 41 T, 80TLR, 131 S + 163 T, 156DA, 158 T, 163LS/G | 138 K, 177KT, 193PL3, 267QE | 13FE, 47 F, 56EDR11, 56EEDR11, 57DE, 57DEDP, 96EV | 52PQ2, 52PR, 74SR3, 74SV2, 77 R, 125SQ, 140A2 |
| (2) | (6) | (4) | (7) | (7) | |
| 4. | 62EE, 65GK, 82LR + 138 M, 144KR + 127 K | 65QIA, 65QIA + 76ESN, 69AA + 65QI, 70IAQ, 131 S + 163 T, 158 T, 163EW, 163EW + 66I, 163EW + 73TE, 180E | 193PL3, 267QE | 47 F, 56EDR11, 56EEDR11, 57DE, 57DEDP | - |
| (4) | (10) | (2) | (5) | (0) | |
| 5. | 62EE, 65GK, 80I, 80I + 90 A, 82LR + 138 M, 144KR, 144KR + 127 K, 144KR + 151H, 166DG | 41 T | – | 37YV, 56EDR11, 56EEDR11, 57DE, 57DEDP, 70D, 70DA | 45EV |
| (9) | (1) | (0) | (7) | (1) | |
| 6. | 43Q + 62GER, 62GE, 62GK2, 79GT + 90D, 107 W, 144TKH, 145KHA, 151AHA, 163 R, 163RW | 44RT, 44RT + 69TNT, 65QIA, 69AA, 69AA + 65QI, 69AA + 76E, 80I + 69TNT, 82LR + 138 T, 82LR + 144QR | 80 K, 80 K + 14 R | 13FE, 70DA, 70QT, 73 A, 96EV, 142M3 | 37YV, 45 GV, 46VY3, 52PQ2, 52PR, 74SR3, 74SV2, 125SQ |
| (10) | (9) | (2) | (6) | (8) | |
| 7. | 66NV, 151AHA, 163RW | 44RT, 44RT + 69TNT, 65QIA, 69AA, 69AA + 65QI, 69AA + 76E, 80I, 80I + 69TNT, 80I + 90 A, 82LR + 144QR, 82LR + 145 R, 82LR + 145RA, 163LW, 163LW + 65QIT | 21H, 65QKR + 76VS | 13FE, 70DA, 70QT, 73 A, 96EV, 142M3 | 37YV, 45 GV, 46VY3, 52PQ2, 52PR, 74SR3, 74SV2, 125SQ |
| (3) | (14) | (2) | (6) | (8) | |
| 8. | 62QE + 56 G, 66NV, 79GT + 90D, 90D, 138MI, 138MI + 79GT, 144KR, 144KR + 151H, 151AHA, 163 R, 163RW | 69TNT + 80 N, 71ATD, 71TTS, 76ESN, 80 N, 80TLR, 131 S + 163 T, 158 T | – | – | 45 GV, 52PQ2, 52PR, 140A2 |
| (11) | (8) | (0) | (0) | (4) | |
| 9. | 43Q + 62GER, 62GE, 62GK2, 62LQ, 76ANT, 107 W, 127 K, 144TKH, 145KHA, 253Q | 41 T, 44RMA, 80TLR, 82LR, 82LR + 90 A, 82LR + 138 T, 82LR + 144QR, 82LR + 145 R, 82LR + 145RA, 144QL, 163EW, 163EW + 66I, 163EW + 73TE, 163LS/G | 73AN, 90D | 25Q3, 57 V, 70D, 78V2, 98E, 104 A, 181 M | – |
| (10) | (14) | (2) | (7) | (0) |
Antibody-verified eplet mismatches in HLA-A,- B,- C, -DRB1 and -DQB1 antigens between Treg and ASC donors are listed and HLA eplet mismatch load for each studied allele pair is given in brackets.