Table 1.

The lasR core regulon.

Locus Tag	Gene Name	Locus Tag	Gene Name	Locus Tag	Gene Name
PA14_00650	–	PA14_21000	–	PA14_40310	–
PA14_01490	–	PA14_21010	–	PA14_41500	–
PA14_01760	nuh	PA14_21020	–	PA14_42910	–
PA14_02220	–	PA14_21030	–	PA14_42940	–
PA14_07430	–	PA14_26020	–	PA14_42950	–
PA14_09400	phzS	PA14_30570	potF	PA14_42960	–
PA14_09410	phzG1	PA14_30580	–	PA14_42970	–
PA14_09420	phzF1	PA14_30620	–	PA14_42980	–
PA14_09440	phzE1	PA14_30630	pqsH	PA14_42990	–
PA14_09450	phzD1	PA14_31150	–	PA14_43000	–
PA14_09460	phzC1	PA14_31290	pa1L	PA14_43020	–
PA14_09470	phzB1	PA14_31360	–	PA14_43030	–
PA14_09480	phzA1	PA14_32590	dipZ2	PA14_43040	–
PA14_09490	phzM	PA14_32600	–	PA14_43050	–
PA14_09700	pqsL	PA14_32610	dsbG	PA14_43090	–
PA14_09900	prpL	PA14_33290	–	PA14_45940	lasI
PA14_10360	–	PA14_33450	treA	PA14_45950	rsaL
PA14_10380	–	PA14_34020	–	PA14_46510	–
PA14_10490	–	PA14_34330	–	PA14_46520	–
PA14_10500	ccoN	PA14_34810	mxaA	PA14_46530	–
PA14_10530	–	PA14_34820	–	PA14_46540	–
PA14_10540	fixG	PA14_34830	–	PA14_46550	–
PA14_10550	cysI	PA14_34840	–	PA14_48040	aprI
PA14_10560	–	PA14_34870	chiC	PA14_48060	aprA
PA14_13360	–	PA14_36310	hcnC	PA14_48090	aprF
PA14_13370	–	PA14_36320	hcnB	PA14_48100	aprE
PA14_13380	–	PA14_36330	hcnA	PA14_48115	aprD
PA14_13390	–	PA14_36530	–	PA14_48140	aprX
PA14_15090	-	PA14_36620	–	PA14_49260	napB
PA14_16250	lasB	PA14_36820	–	PA14_49310	–
PA14_18630	eprS	PA14_37745	–	PA14_51350	phnB
PA14_19100	rhlA	PA14_37760	–	PA14_51380	pqsE
PA14_19110	rhlB	PA14_37770	–	PA14_51390	pqsD
PA14_19120	rhlR	PA14_37780	–	PA14_51410	pqsC
PA14_19130	rhlI	PA14_38260	–	PA14_51420	pqsB
PA14_19870	ldh	PA14_39880	phzG2	PA14_51430	pqsA
PA14_19900	–	PA14_39890	phzF2	PA14_53250	cpbD
PA14_19910	pdhB	PA14_39910	phzE2	PA14_55080	–
PA14_20610	lecB	PA14_39925	phzD2	PA14_55940	–
PA14_20900	–	PA14_39945	phzC2	PA14_60750	pra
PA14_20920	–	PA14_39960	phzB2	PA14_61870	–
PA14_20940	-	PA14_39970	phzA2	PA14_63170	cueR
PA14_20950	fabH2	PA14_40180	–	PA14_66840	phaC2
PA14_20960	–	PA14_40200	–	PA14_68930	–
PA14_20970	cyp23	PA14_40290	lasA	PA14_68940	–
PA14_20980	–	PA14_40300	–	PA14_69560	hcpB

The core regulon was defined as the (n = 138) genes that showed a log₂FC ≤ −1 (corrected p-value ≤ 0.05) in at least 19 of overall 21 lasR* compared to 28 lasR^WT isolates and were significantly downregulated (log₂FC ≤ −1) in PA14 ∆lasR compared to PA14 WT. Cells were grown in LB at 37 °C and 180 rpm shaking until an OD₆₀₀ = 2.